Phosphatidylserine: The Ultimate Guide to Cognitive Enhancement and Stress Management

What Is Phosphatidylserine?

Phosphatidylserine, often abbreviated as PS, is a phospholipid that consists of a glycerol backbone, two fatty acids, and a phosphate group. It is a crucial component of cell membranes, particularly in the brain, where it contributes to the structure, fluidity, and functionality of neuronal cells.  

Phosphatidylserine is classified as a phospholipid due to its unique composition, containing both hydrophobic and hydrophilic regions that facilitate membrane formation. It is naturally found in egg yolk, liver and soya beans.

Phosphatidylserine is commonly employed to address Alzheimer's disease and the natural cognitive decline that comes with aging. It is sometimes utilized to enhance athletic performance, manage ADHD, and serve various other purposes. However, it is important to note that there is limited scientific evidence to substantiate the majority of these applications.


Nootropic Benefits Of Phosphatidylserine

Phosphatidylserine (PS) demonstrates its potential in supporting a range of cognitive functions in humans. These include:

  • Formation of Short-Term Memory: PS plays a role in the initial encoding and retention of information in short-term memory. It helps in the process of acquiring new knowledge and experiences, allowing them to be temporarily stored for immediate use.
  • Consolidation of Long-Term Memory: PS aids in the transfer of information from short-term memory to long-term memory storage. By facilitating the consolidation process, PS promotes the formation of lasting memories, allowing for easier retrieval in the future.
  • Attention and Concentration: PS has been found to have a positive impact on attention and concentration. It helps to enhance focus and sustain the mental effort, allowing individuals to better engage with tasks and filter out distractions.
  • Reasoning and Problem-Solving: PS may play a role in enhancing reasoning skills and problem-solving abilities. By optimizing brain cell membranes and supporting neurotransmission, PS facilitates efficient communication between brain regions involved in cognitive processes, leading to improved reasoning and problem-solving capabilities.
  • Language and Communication Skills: PS is thought to contribute to language and communication skills. It aids in the efficient processing and retrieval of linguistic information, facilitating verbal expression, comprehension, and effective communication.

How does It Work For The Brain?


·      Helps In Brain Regeneration

Phosphatidylserine (PS), a crucial nutrient, acts as a building block for phospholipids, aiding in the creation, maintenance, and repair of brain cells. Its significance lies particularly in the formation of cell membranes.

Diminishing levels of phospholipids like PS in brain cell membranes have been associated with brain degeneration, including cognitive decline associated with aging.


·      Provides Brain Protection

When brain cells cease functioning, they can become toxic. PS plays a role in signaling the immune system to identify and eliminate these deteriorating brain cells before they pose a threat. This mechanism helps safeguard neighboring cells from toxic damage.


PS has also been suggested to protect the brain and body from the detrimental effects of stress by potentially reducing the release of the stress hormone cortisol. Its anti-stress effects may contribute to improvements in mood and mental clarity.

·      Provides Brain Energy

A human study found a significant increase in brain glucose metabolism following PS supplementation. Specifically, the basal ganglia/thalamus experienced a 20.3% increase, while the visual cortex exhibited a 19.3% increase. This suggests that PS supplementation may boost brain energy levels.

·      Stimulate The Production Of Brain Chemicals

Animal research indicates that PS can stimulate the production of the neurotransmitter acetylcholine. Furthermore, by supporting the proper functioning of brain cell membranes, PS aids in the regulation of brain chemicals, as healthy cell membranes facilitate effective neurotransmission.


Dosage And Safety

  • Phosphatidylserine is commonly taken orally by adults at doses ranging from 200 to 400 mg per day, typically for a period of 1 to 3 months.
  • It is important to consult with a healthcare provider to determine the optimal dosage for specific health conditions.
  • Previously, many phosphatidylserine supplements were derived from cow brains, which raised concerns about the potential transmission of animal diseases such as mad cow disease to humans. However, there have been no reported cases of such transmission.


Potential Side Effects

  • When consumed orally, Phosphatidylserine is generally considered safe for short-term use, up to a duration of 3 months. However, it is important to note that higher doses exceeding 300 mg may lead to side effects such as insomnia and stomach discomfort.
  • There is a level of concern regarding the potential transmission of diseases, such as mad cow disease, through phosphatidylserine supplements derived from animal sources.
  • Thus far, there have been no reported cases of humans contracting animal diseases from phosphatidylserine supplements. Nonetheless, it is advisable to err on the side of caution and opt for supplements derived from plant sources to ensure safety.

How To Take Phosphatidylserine

Phosphatidylserine can be taken at any time during the day. However, some individuals find it beneficial to take it in the morning or early afternoon to support cognitive function throughout the day. It is generally suggested to avoid taking it too close to bedtime to prevent potential sleep disturbances.

 Phosphatidylserine can be stacked with other nootropics to enhance cognitive performance. However, it is important to research and understands the interactions between different substances before combining them

Personal Experiences:

Personal accounts of individuals who have taken phosphatidylserine may vary. Some users report positive experiences with improved memory, focus, and cognitive performance. Others may have different responses or minimal noticeable effects.

One user said that “I was having difficulty remembering the name of things or finishing sentences...or even remembering the topic! Trying to lecture at the university was a struggle. Within 2 weeks I could tell a HUGE difference!!! I feel 15 years younger, and I am no longer groping for words”.

Another user said “I am almost 91 years of age and a writer. I just published a book on Amazon last summer and hope to publish another one soon. This product includes bovine, which is great for the brain, and w/out soy. My experience with the product is very good. I wish I'd known about it years ago”!


Comparison With Other Nootropics

  • Omega-3 Fatty Acids: Provide structural support to brain cell membranes, while phosphatidylserine affects cell membrane fluidity and neurotransmission.
  • Gingko Biloba: Enhances blood flow and exhibits antioxidant properties, while phosphatidylserine supports memory, attention, and reasoning through neurotransmission and cell membrane function.
  • Bacopa Monnieri: Modulates neurotransmitters and reduces oxidative stress, while phosphatidylserine aids in memory formation and retrieval via cell membrane fluidity and neurotransmission.
  • Alpha-GPC: Acts as a precursor for acetylcholine synthesis, while phosphatidylserine influences cell membrane functionality and neurotransmission.

Future Research

While there is already a significant body of research supporting the cognitive-enhancing benefits of, phosphatidylserine there is still much to be learned about this plant and its potential uses. Future research may explore the effects of phosphatidylserine on other aspects of health and wellness, as well as potential long-term effects and optimal dosages.



Phosphatidylserine has emerged as a promising nootropic ingredient with potential cognitive benefits. It plays a crucial role in supporting various cognitive functions, including memory formation, attention, and reasoning, by influencing cell membrane fluidity and neurotransmission. Furthermore, it has been associated with brain protection, stress reduction, and potentially positive effects on mood and mental clarity.


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